LIGAND-BASED PREDICTION OF HERG-MEDIATED CARDIOTOXICITY BASED ON THE INTEGRATION OF DIFFERENT MACHINE LEARNING TECHNIQUES

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Drug-induced cardiotoxicity is a common side effect of drugs in clinical use or under postmarket surveillance and is commonly due to off-target interactions with the cardiac Delivery-Fee human-ether-a-go-go-related (hERG) potassium channel.Therefore, prioritizing drug candidates based on their hERG blocking potential is a mandatory step in the earl

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Cover the Antique. The case of the Arena of Verona

The International Competition for Verona Arena Coverage has animated the international debate Funko on the theme of contemporary intervention on ancient architecture.The NFRG of Politecnico of Bari has proposed an experimental, reversible, modular and structurally independent roofing Cooling Racks/Grates solution.Starting from the study of the vela

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A Comparative Study on the Impact of One-Way and Two-Way Matching Strategies on the Evolution of Cloud Manufacturing Ecosystems

The supply-demand matching (SDM) strategy is an important part of the transaction mechanism design of cloud manufacturing (CMfg) platforms, which has a significant impact on the evolution trend of cloud manufacturing ecosystems (CMEs).To help CMfg platform operators choose the appropriate SDM strategy, first, the evolution process of the CME was qu

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Assessment of the mechanical properties and antimicrobial efficiency of orthodontic adhesive modified with Salvadora Persica oil

Objectives.This study examines the mechanical properties and antimicrobial effectiveness of orthodontic adhesive enhanced with Salvadora persica (SP) oil.It includes assessments of adhesive remnant index (ARI), shear bond strength (SBS), and evaluates its antimicrobial efficacy against Streptococcus mutans.Methods.Forty freshly extracted human prem

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